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KMID : 0613820070170020248
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Journal of Life Science
2007 Volume.17 No. 2 p.248 ~ p.253
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The Effects of Diesel Exhaust Particulates and Particulate Matters on the Airway Remodeling in the Asthma-induced Mice
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Li Tianzhu
Lee Soo-Jin
Jang Yang-Ho
Park Jun-Hong
Lee Jung-Hak
Choe Nong-Hoon
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Abstract
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This research investigated whether exposure of diesel exhaust particulate (DEP) and particulate matter (PM) effects on airway remodeling in asthma induced Balb/c and IL-10 knock out (KO) mouse. Mice were sensitized with intraperitoneal injection with ovalbumin, followed by challenges with intranasal ovalbumin. After that mice placed in inhalation chamber and exposed to DEP and PM(10 mg/m³). The evidence of airway remodeling was assessed by masson’s trichrome staining and PAS staining. The stainability of masson’s trichrome and PAS reaction were increased in asthma-induced Balb/c mice groups compared with control mice groups. More intensive stainability for masson’s trichrome and PAS were appeared in the asthma-induced DEP and PM-exposed groups than asthama-induced groups. But, not significantly increased subepithelial fibrosis and the nember of goblet cell hyperplasia in asthma-induced IL-10 KO mice groups and asthma-induced+DEP and PM-exposed IL-10 KO mice than IL-10 KO mice groups. These results indirectly suggesting that exposure to DEP and PM in asthmatic patients might be aggravate clinical symptoms and IL-10 which seems to play a central role in allergic asthma. In conclusion, DEP and PM exposure might have additive effects on the ovalbumin- induced asthma in a murine model.
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KEYWORD
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Asthma-induced mouse, IL-10 KO mouse, Airway remodeling, DEP and PM
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